Products

*Any information on this list of our products available in Japan is not intended to promote or advertise any of the products.

As of September 2025

Brand Name Launch Indications Licensor
1 NOBELZIN®
(for Wilson's disease (copper absorption inhibitor))
Apr-08 Wilson’s disease Teva
2 LUNABELL® LD
(for dysmenorrhea)
Jul-08 dysmenorrhea Janssen
3 NOBELBAR®
(anticonvulsant)
Dec-08 neonatal seizures,
status epilepticus
In-house/
Kagawa Univ
4 Fostoin®
(anticonvulsant)
Jan-12 status epilepticus,
prevention of postoperative seizures, etc.
Pfizer
5 INDACIN®
(for patent ductus arteriosus in prematurity)
Jan-13 patent ductus arteriosus of prematurity Lundbeck
6 COSMEGEN®
(antitumor antibiotic)
Jan-13 Wilms’ tumor,
chorionepitelioma,
pediatric solid malignant tumor, etc.
Lundbeck
7 LUNABELL® ULD
(for dysmenorrhea)
Sep-13 dysmenorrhea Janssen
8 Unitalc®
(for pleurodesis)
Dec-13 prevention of recurrent malignant pleural effusion Novatech/
Nagoya Medical Center
9 Respia®
(for apnea of prematurity)
Dec-14 apnea of prematurity Nippon Boehringer
(co-development)
10 RAPALIMUS®
(mTOR inhibitor)
Dec-14 lymphangioleiomyomatosis Pfizer/
Niigata Univ
11 ZANOSAR®
(antineoplastic)
Feb-15 gastroenteropancreatic neuroendocrine tumor ESTEVE (former Keocyt)
12 NOBELZIN® Tablets
(hypozincemia)
Mar-17 hypozincemia (new indication) In-house
13 RAPALIMUS® Gel
(for tuberous sclerosis-associated skin lesions (mTOR inhibitor))
Jun-18 tuberous sclerosis-associated skin lesions Osaka Univ/
In-house
14 TITANBRIDGE®
(thyroid cartilage fixation device)
Jul-18 adductor spasmodic dysphonia TRI
(Translational Research Center
for Medical Innovation)/
Kumamoto Univ
15 JEMINA®
(for dysmenorrhea)
Oct-18 dysmenorrhea In-house
16 RETYMPA®
(for tympanic membrane perforation)
Dec-19 tympanic perforation TRI/
Kaken
17 Melatobel®
(melatonin receptor agonist for sleep onset improvement)
Jun-20 Sleep-onset difficulty associated with neurodevelopmental disorder in children In-house
18 RAPALIMUS®
(mTOR inhibitor)
Sep-21 refractory lymphatic disease [lymphangioma (lymphatic malformation), lymphangiomatosis, Gorham's disease, lymphangiectasia]
(new indication)
Gifu Univ
19 Unitalc®
(for pleurodesis)
Mar-22 Inoperable Secondary Intractable Pneumothorax
(new indication)
Nagoya Medical Center
20 LUNABELL®LD/ULD
(for dysmenorrhea)
Mar-22 adjustment for Initiation of controlled ovarian stimulation in assisted reproductive technology
(new indication)
In-house
21 JEMINA®
(for dysmenorrhea)
Mar-22 adjustment for Initiation of controlled ovarian stimulation in assisted reproductive technology
(new indication)
In-house
22 NOBELZIN® Granules
(for Wilson's disease (copper absorption inhibitor))(hypozincemia)
Feb-23 Wilson's disease, hypozincemia National Center for Child Health and Development All rights reserved.
23 RAPALIMUS®
(mTOR inhibitor)
Jan-24 Lymphangioleiomyomatosis
The following intractable vascular tumors and intractable vascular malformations:
- Lymphatic malformation,
- Generalized lymphatic anomaly,
- Gorham-Stout disease,
- Lymphangiectasia
- Hemangioendothelioma, tufted angioma
- Venous malformation, blue rubber bleb nevus syndrome
- Complex-combined vascular malformation, Klippel-Trenaunay-Weber syndrome
Gifu Univ
24 RAPALIMUS® Granules 0.2%
(mTOR inhibitor)
Jul-24 The following intractable vascular tumors and intractable vascular malformations:
- Lymphatic malformation,
- Generalized lymphatic anomaly,
- Gorham-Stout disease,
- Lymphangiectasia
- Hemangioendothelioma, tufted angioma
- Venous malformation, blue rubber bleb nevus syndrome
- Complex-combined vascular malformation, Klippel-Trenaunay-Weber syndrome
Gifu Univ
25 Sargmalin® for inhalation 250 µg
(for autoimmune pulmonary alveolar proteinosis(APAP))
Jul-24 Autoimmune Pulmonary Alveolar Proteinosis Partner Therapeutics/
Niigata Univ
26 Zintus® Tablets 50 mg
(hypozincemia)
Aug-24 Hypozincemia In-house
27 KBM LineCheck APAP
(Anti GM-CSF antibody kit )
Dec-24 Anti-GM-CSF Antibody Detection Kit “KBM LineCheck APAP” Launched Kohjin Bio Co., Ltd.
28 ACENOBEL®Sustained Release Tablet 500 mg
(for Distal Myopathy with Rimmed Vacuoles)
Dec-24 Distal Myopathy with Rimmed Vacuoles In-house
29 Melatobel® Tablet 1 mg/2 mg
(melatonin receptor agonist for sleep onset improvement)
Jul-25 sleep-onset difficulty associated with neurodevelopmental disorder in children In-house
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