Pipeline

Nobelpharma committed to development of critical but neglected drugs in order to fulfill social mandate

We have constantly been aspiring to conduct research and development of drugs, that are not the prime targets for many pharmaceutical companies due to questionable economic viability with a small number of patients (drugs for unmet medical needs). Our development pipeline mainly includes the drugs such as orphan drugs (drugs for rare diseases) that have been strongly requested by patients, academic societies, or the government, as well as off-label drugs and pediatric medicines. The efficient research and development processes by our small but highly capable organization is what enables us to obtain approvals for such drugs with a comparatively small market size.
While we heretofore have engaged in the development of many unapproved drugs, that were already available in US and Europe but were not developed in Japan despite their significant need, we will also actively take on the challenges of research and development under new and different concepts.

Development Process of Nobelpharma

Development Process of Nobelpharma

Future Development Projects

The pipeline shows the developmental status of an unapproved drug or an unapproved indication and is not intended to promote or advertise any of the drugs.

  • Note: Indicagtions and Approval are merely the expectations.

New Drugs/New Devices (including global development projects)

As of April 2024

Compound Expected
Indication
Partner Phase Expected MA
NPC-25
zinc histizine hydrate
hypozincemia In-house approved -
NPC-09
aceneuramic acid
suppression of progressive muscle weakness in
GNE myopathy
in-house approved -
NPC-26
sargramostim
autoimmune pulmonary alveolar proteinosis Partner Therapeutics
Niigata Univ
approved -
NPC-22
scopolamine
hypersalivation Kitasato Univ P-II / III in prep Mar 2027
NPC-21
anti-CMV antibody
CMV infection Evec P-II -
NPC-29
ubiquinol
multiple system atrophy Tokyo Univ P-II -
NPC-30
(GAIA-102)
high-active NK-like cells
neuroblastoma GAIA BioMedicine
Kyushu Univ
P-I -
NPC-31
P092 maleic acid
prion disease Gifu Univ P-I in prep -

Life Cycle Management (including global development projects)

As of April 2024

Compound Expected
Indication
Partner Phase Expected MA
NPC-06
Fostoin
neural field
(new indication)
Pfizer P-III Mar 2026
NPC-18
RETYMPA
ear canal regeneration
(new indication)
Kaken P-III Dec 2026
NPC-12
RAPALIMUS
epilepsy with focal cortical dysplasia type II (new indication) Showa Univ P-III Jun 2026
NPC-12
RAPALIMUS
Pendred syndrome/DFNB4
(new indication)
Keio Univ
Kitasato Univ
P-II -
NPC-12
RAPALIMUS
primary immunodeficiency syndrome
(new indication)
Tokyo Medical and Dental Univ
National Defense Medical College
P-II -
NPC-12
RAPALIMUS
generalized scleroderma
(new indication)
Oita Univ P-I / II -
NPC-12G
RAPALIMUS Gel
vascular abnormality-associated skin lesions
(new indication)
in-house P-III in prep
(multi-national clinical trial)
-
NPC-15
Melatobel
sleep-onset difficulty associated with mild cognitive disorder or dementia
(new indication)
in-house P-II -
NPC-15
Melatobel
xeroderma pigmentosum
(new indication)
Kobe Univ P-II -
NPC-26
salgramostim
non-tuberculous mycobacterial disease
(new indication)
Niigata Univ P-II -

Overseas Development

As of April 2024

Compound Expected
Indication
Partner Phase Expected MA
NPC-02
(NOBELZIN)
Wilson’s disease - CH approved -
NPC-15
(MELATOBEL)
Sleep-onset difficulty associated with neurodevelopmental disorder in children - CH filed Feb 2024
NPC-17
thyroid cartilage fixation device
(TITANBRIDGE)
adductor spasmodic dysphonia - US trial in prep -
EU CE marking in process Aug 2025
NPC-16
(JEMINA)
dysmenorrhea - CH P-III in prep Dec 2028
NPC-18
(RETYMPA)
tympanic perforation MEEI/
Harvard Univ/
New York Univ
US P-II -
Research and Development

R&D of Nobelpharma

Pipeline

Products

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